오메가-3는 조기 발병 치매 위험과 반비례 관계입니다

Omega-3 is inversely related to risk of early-onset dementia

141 pointsby brandonb2026. 2. 8.77 comments

요약

UK 바이오뱅크 데이터를 이용한 연구에서 40-64세 개인의 혈중 오메가-3 수치와 조기 발병 치매(EOD)의 관계를 분석했습니다. 결과는 높은 총 오메가-3 수치와 EOD 위험 간의 통계적으로 유의미한 반비례 관계를 보여주었으며, 이는 젊은 시절 오메가-3 섭취를 늘리는 것이 질병의 발병을 늦추는 데 도움이 될 수 있음을 시사합니다.

HPsquared•3시간 전

I wonder how much of this is Omega-3 in the diet, or if there are processes that could deplete levels in the blood.

cpncrunch•2시간 전

Abstract says blood levels objectively reflect dietary intake.

DonThomasitos•3시간 전

Cool! But isn‘t that already common wisdom and the basis for the omega3 fanboy culture?

dude250711•3시간 전

Just a stepping stone towards Omega 6, 9 and ultimately 7 grindset...

hmontazeri•2시간 전

I bet this is due to omega 3 reducing inflammation and oxidative stress

deeth_starr_v•2시간 전

> Compared to participants at Q1 of DHA, those at Q5 of non-DHA showed a significant lower risk of EOD. A statistically significant lower risk was observed in Q3, Q4 and Q5 of non-DHA omega-3

If I'm reading this right, if you can't get many fish sources in your diet, it's better to increase the quantity of non-DHA sources (certain seeds, oils and vegetables). But my understanding is non-DHA is not helpful so I may not be understanding correctly

Qem•2시간 전

> But my understanding is non-DHA is not helpful so I may not be understanding correctly

Alpha-linolenic acid (ALA), the Omega-3 present in most plant sources, can get its chemical structure lenghtened to EPA and DHA in the organism. The problem appears to be, when people get older, the efficiency of this conversion takes a large hit.

Faelon•2시간 전

I think it's easy to take algal-based omega-3 supplements. They've gotten pretty good in the last couple years with gummies with a high dose and no algae test. And no fish killed!

unsupp0rted•2시간 전

I would recommend it to elderly family members, but they have atrial fibrillation, and I heard omega 3 can exacerbate it?

staticassertion•2시간 전

It's seemingly dose dependent. Low omega 3 can seems to have the same mechanistic effect. As for what the dose should be? No clue, personally, and it depends on your heavily diet since even one fishy meal could provide as much as most supplements do. Personally, I don't eat much fish, so I'm comfortable with a supplement. If I ate even one piece of salmon in a day I'd skip the supplement that day.

If I had afib I'd talk to a doctor about it before taking it and probably would stay well under 1G on any day I don't eat fish and skip it entirely on a day that I do.

Not a dr, not a health professional, not anyone you should listen to perhaps at all, but this is my understanding.

MarkMarine•2시간 전

What’s missing from this is how much omega 3 containing food, how often you need to get this protective result.

Do I need to eat fish twice a week? 5 times? Do I need to supplement because there is no way to eat enough fish?

Would love some practical guidance tacked on to this

boston_clone•1시간 전

I like to get my omegas from the following sources, no fish needed!

- hemp hearts (complete protein, goes best with oatmeal for breakfast, on salads, or in soups for an extra bit of nutty / fatty flavor)

- pumpkin seeds (also good source of iron, iirc)

- algae-based supplement (currently taking an omega3 + vit D + vit K combo capsule from nordic naturals)

svara•1시간 전

It's really unclear unfortunately.

The correlative effect is quite clear, i.e people who have high omega 3 levels (eat a lot of fish) have health benefits.

But in random controlled trials Omega 3 supplements have not had convincing effects.

It might be because the supplements aren't very good, or because there's actually something completely different going on, like fish displaces less healthy foods from the diet.

djoldman•2시간 전

Studies like this always seem to cite stats in a way that's pretty inaccessible to me. This is more clear to me:

* 217,122 participants whose data was extracted from the UK biobank database

* Out of those 217,122, 325 got early onset dementia over an average of 8.3 years

* The vast percentage of data came from exactly one blood draw per person between 2006 and 2010 at the beginning of the biobank study

  Omega-3 Blood      | Hazard Risk      | Rate of Incidence  | Percent Incidence
  Level Quintiles    |                  | Over 8.3 Years     | Over 8.3 Years
  -------------------|------------------|--------------------|------------------
  Q1 (Lowest 20%)    | 1.0              | 193 in 100,000     | 0.193%
  Q4 (High)          | 0.62             | 120 in 100,000     | 0.120%
  Q5 (Highest 20%)   | 0.60             | 116 in 100,000     | 0.116%

getnormality•1시간 전

This could significantly underestimate the real impact. A single point measurement is perhaps a pretty noisy measure of long term average. If we had lifetime averages, the quintiles would be more purely differentiated by the variable of interest, and the risk would be as well.

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46493168•2시간 전

Are vegan sources of omega 3 worth it or am I fucked

Manfred•1시간 전

Seaweed :)

FeteCommuniste•1시간 전

Just use an algae-based omega-3 supplement. Eating algae is how fish build up omega-3 levels in their bodies anyway.

andyjohnson0•1시간 전

Not sure where you are located, but here in the UK supermarkets (eg Tesco) sell vegan omega 3/6/9 capsules.

scns•1시간 전

Should be, that's where the fish get it from.

boston_clone•1시간 전

very worth it! seven years here with no negative health effects noticed; plus, you’re saving animal lives and helping sustain the planet.

natural sources for omega FAs include hemp hearts and pumpkin seeds.

pengaru•2시간 전

I suspect the positive effects of consuming nutritious forms of fish-centric meals has as much to do with what you're _not_ eating in those meals as contents like omega-3s.

There's a bunch of less harmful stuff you can fill your diet with that just by virtue of displacing terrible things has positive effects.

raffa667•2시간 전

https://blog.ncase.me/on-depression/ - I think this is explained in a better and simpler way

midtake•2시간 전

It's difficult if not impossible to increase your intake of omega-3 without increasing your intake of omega-6 even more. I am not sure that's worth it.

ipaddr•2시간 전

Not sure I understand. Replacing chicken with salmon seems simple. So does eating walnuts.

Aldipower•1시간 전

Linseed oil.

the_pwner224•1시간 전

The O3:O6 ratio matters more. And with the right diet it's very easy to get tons of O3 with an excellent O6 ratio (1:4 vs. the 1:10+ of the standard western diet). Vegan with some seeds (hemp, flax, chia, etc.) and a fish oil or algal EPA/DHA supplement will do it quite easily. As long as you use olive/avocado oil over the O6-heavy cooking oils. Other diets are probably also capable of this.

insuranceguru•2시간 전

from an actuarial perspective, these longitudinal studies on dementia are huge. early-onset is basically the hardest risk to price for long-term care because the tail of the claim is so long and expensive. finding a solid inverse correlation like this is the kind of thing that eventually shifts premium modeling for an entire generation.

getnormality•1시간 전

Too bad the LTC industry is kinda dead!

ck2•1시간 전

Studies also show you do NOT need DHA and DHA can be detrimental, you want pure EPA or very high EPA to DHA ratio

if you want the purest Omega3 EPA without all the contaminants that are in OTC supplement nonsense (they are completely unregulated and untested by batch)

ask your doctor for a script of generic VASCEPA

CostPlusDrugs has the cheapest generic Vascepa that I've found

The dose is usually two pills a day but trust me on this, start with one for a long time, it takes your GI a long time to handle it without bathroom urgency

https://pmc.ncbi.nlm.nih.gov/articles/PMC5282870/

https://www.youtube.com/watch?v=3uoQUM30Ess

akashnagar•1시간 전

Highly underrated

오메가-3는 조기 발병 치매 위험과 반비례 관계입니다

요약

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